St. Louis is the second-largest city in Missouri, United States. It is located near the confluence of the Mississippi and the Missouri rivers. Before European settlement, the area had been occupied for thousands of years by various Native American cultures. From roughly 900 to 1500 CE, it was a regional center of Mississippian culture, based in Cahokia east of the river, and extending across the continent along the Mississippi and its tributaries.St. Louis is the second-largest city in Missouri, United States. It is located near the confluence of the Mississippi and the Missouri rivers. Before European settlement, the area had been occupied for thousands of years by various Native American cultures. From roughly 900 to 1500 CE, it was a regional center of Mississippian culture, based in Cahokia east of the river, and extending across the continent along the Mississippi and its tributaries.

The same year as the 1904 World's Fair, the Strassberger Music Conservatory Building was constructed at 2300 Grand. Otto Wilhelmi was the architect. In 1911, the conservatory had over 1,100 students. The building is presently in the National Register of Historic Places. A well known graduate was Alfonso D'Artega.

With its French past and waves of Catholic immigrants in the 19th and 20th centuries, from Ireland, Germany and Italy, St. Louis is a major center of Roman Catholicism in the United States. St. Louis also boasts the largest Ethical Culture Society in the United States and is one of the most generous cities in the United States, ranking ninth in 2013. Several places of worship in the city are noteworthy, such as the Cathedral Basilica of St. Louis, home of the world's largest mosaic installation.

Other notable churches include the Basilica of St. Louis, King of France, the oldest Roman Catholic cathedral west of the Mississippi River and the oldest church in St. Louis; the St. Louis Abbey, whose distinctive architectural style garnered multiple awards at the time of its completion in 1962; and St. Francis de Sales Oratory, a neo-Gothic church completed in 1908 in South St. Louis and the second largest church in the city.

The city is identified with music and the performing arts, especially its association with blues, jazz, and ragtime. St. Louis is home to the St. Louis Symphony, the second oldest symphony orchestra in the United States. Until 2010, it was also home to KFUO-FM, one of the oldest classical music FM radio stations west of the Mississippi River. Opera Theatre of St. Louis has been called "one of America's best summer festivals" by the Washington Post. Former general director Timothy O'Leary was known for drawing the community into discussions of challenging operas. John Adams's "The Death of Klinghoffer", which touched off protests and controversy when performed by the Metropolitan Opera in 2014, had no such problems in St. Louis three years before, because the company fostered a citywide discussion, with interfaith dialogues addressing the tough issues of terrorism, religion and the nature of evil that the opera brings up. St. Louis's Jewish Community Relations Council gave O'Leary an award. Under O'Leary, the company—always known for innovative work—gave second chances to other major American operas, such as John Corigliano's "The Ghosts of Versailles", presented in 2009 in a smaller-scale version.

The Gateway Arch anchors downtown St. Louis and a historic center that includes: the Federal courthouse where the Dred Scott case was first argued, an expanded public library, major churches and businesses, and retail. An increasing downtown residential population has taken to adapted office buildings and other historic structures. In nearby University City is the Delmar Loop, ranked by the American Planning Association as a "great American street" for its variety of shops and restaurants, and the Tivoli Theater, all within walking distance.

Unique city and regional cuisine reflecting various immigrant groups include toasted ravioli, gooey butter cake, provel cheese, the slinger, the Gerber sandwich, and the St. Paul sandwich. Some St. Louis chefs have begun emphasizing use of local produce, meats and fish, and neighborhood farmers' markets have become more popular. Artisan bakeries, salumeria, and chocolatiers also operate in the city.

St. Louis-style pizza has thin crust, provel cheese, and is cut in small squares. Frozen-custard purveyor Ted Drewes offers its "Concrete": frozen custard blended with any combination of dozens of ingredients into a mixture so thick that a spoon inserted into the custard does not fall if the cup is inverted.